Esteemed ISD member, Professor Sir John Gurdon, Gurdon Institute, Cambridge, UK, was awarded the Nobel Prize for Physiology or Medicine in 2012. The 2012 Nobel Prize is shared jointly with Professor Shinya Yamanaka, Kyoto University, Japan.
Having carried out, nearly half a century ago, the key early nuclear transfer experiments demonstrating the conservation of the genome during the process of cell differentiation, John pioneered the use of amphibian oocytes and eggs as living test tubes for the analysis of gene expression at all levels. His past and present work has made major contributions to our understanding of development and cell differentiation, but has also had widespread application to many other problems in molecular and cell biology. Some previous reviews summarize different parts of this work, including a general review in Ann.Rev.Cell Devel.Biol. 22:1-22 (2006) From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation.